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KMID : 0806120150450010118
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대한간호학회지
2015 Volume.45 No. 1 p.118 ~ p.128
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Prevalence and Characteristics of Chemotherapy-related Cognitive Impairment in Patients with Breast Cancer
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Park Jin-Hee
Bae Sun-Hyoung
Jung Yong-Sik
Jung Young-Mi
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Abstract
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Purpose: Evidence suggests that some patients with breast cancer experience cognitive difficulties following chemotherapy. This longitudinalstudy was done to examine the prevalence of cognitive impairment and trajectory of cognitive function over time in women withbreast cancer, who received adjuvant chemotherapy.
Methods: Participants were 137 patients with breast cancer. They completed neuropsychologicaltests and the Functional Assessment of Cancer Therapy?Cognitive Function before adjuvant therapy (pretest), toward theend of adjuvant therapy (posttest), and 6 months after the completion of adjuvant therapy (follow-up test). Of the patients, 91 were treatedwith adjuvant chemotherapy and 46 patients who did not receive chemotherapy made up the comparison group. A reliable-change indexand repeated-measure ANOVA were used for statistical analyses.
Results: At the posttest point, over 30% of patients showed complexcognitive impairment and reported greater difficulty in subjective cognitive function. At the follow-up test point, 22.0% of patients exhibitedcomplex cognitive impairment and 30.8% of patients complained of subjective cognitive impairment. Repeated-measure ANOVA showedsignificant decreases after receiving chemotherapy followed by small improvements 6 months after the completion of chemotherapy incognitive domains of change for attention and concentration, memory, executive function, and subjective cognitive function.
Conclusion:These results suggest that chemotherapy in patients with breast cancer may be associated with objective and subjective cognitive impairments. Further studies are needed to explore the potential risk factors and predictor of chemotherapy-related cognitive changes. Alsonursing interventions for prevention and intervention of cognitive impairments should be developed and tested.
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KEYWORD
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Breast neoplasms, Adjuvant chemotherapy, Attention, Memory, Executive function
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